Galtonosides A-E: Antiproliferative and Antiplasmodial Cholestane Glycosides from Galtonia regalis.,Journal of Natural Products

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Galtonosides A-E: Antiproliferative and Antiplasmodial Cholestane Glycosides from Galtonia regalis.
Journal of Natural Products ( IF 3.3 ) Pub Date : 2020-03-31 , DOI: 10.1021/acs.jnatprod.9b01064
Yongle Du ₁ , Brooke A Martin ₁ , Ana Lisa Valenciano ₂ , Jason A Clement ₃ , Michael Goetz ₃ , Maria B Cassera ₂ , David G I Kingston ₁

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An extract of Galtonia regalis from the Natural Products Discovery Institute showed moderate antiplasmodial activity, with an IC50 value less than 1.25 μg/mL. The two known cholestane glycosides 1 and 2 and the five new cholestane glycosides galtonosides A-E (3-7) were isolated after bioassay-directed fractionation. The structures of the new compounds were determined by interpretation of their NMR and mass spectra. Among these compounds, galtonoside B (4) displayed the most potent antiplasmodial activity, with an IC50 value of 0.214 μM against the drug-resistant Dd2 strain of Plasmodium falciparum.

中文翻译：

Galtonosides AE：来自 Galtonia regalis 的抗增殖和抗疟原虫胆甾烷糖苷。

来自天然产物发现研究所的 Galtonia regalis 提取物显示出中等的抗疟原虫活性，IC50 值低于 1.25 μg/mL。经过生物测定定向分级分离后，分离出了两种已知的胆甾烷糖苷 1 和 2 以及五种新的胆甾烷糖苷半乳糖苷 AE (3-7)。新化合物的结构通过核磁共振和质谱的解释确定。在这些化合物中，galtonoside B (4) 显示出最有效的抗疟原虫活性，对耐药恶性疟原虫 Dd2 菌株的 IC50 值为 0.214 μM。

更新日期：2020-03-31

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