The European Research Network on Signal Transduction (ERNEST): Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling.,ACS Pharmacology & Translational Science

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The European Research Network on Signal Transduction (ERNEST): Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling.
ACS Pharmacology & Translational Science ( IF 4.9 ) Pub Date : 2020-03-31 , DOI: 10.1021/acsptsci.0c00024
Martha E Sommer _{1,

2} , Jana Selent ₃ , Jens Carlsson ₄ , Chris De Graaf ₅ , David E Gloriam ₆ , Gyorgy M Keseru ₇ , Mickey Kosloff ₈ , Stefan Mordalski _{6,

9} , Aurelien Rizk ₁₀ , Mette M Rosenkilde ₁₁ , Eddy Sotelo ₁₂ , Johanna K S Tiemann _{13,

14} , Andrew Tobin ₁₅ , Nina Vardjan _{16,

17} , Maria Waldhoer ₁₀ , Peter Kolb ₁₈

Affiliation

Institute of Medical Physics and Biophysics, Charité-Universitätsmedizin Berlin, Berlin, 10117, Germany.
Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, 13125, Germany.
Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM) - Pompeu Fabra University (UPF), Barcelona, 08003, Spain.
Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, 752 36, Sweden.
Sosei Heptares, Cambridge, CB21 6DG, U.K.
Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, 1017, Denmark.
Medicinal Chemistry Research Group, Research Center for Natural Sciences (RCNS), Budapest, H-1117, Hungary.
Department of Human Biology, University of Haifa, Haifa, 3498838, Israel.
Department of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Krakow, 31-343, Poland.
InterAx Biotech AG, PARK innovAARE, Villigen, 5234, Switzerland.
Laboratory for Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DK 2200, Denmark.
Centro Singular de Investigación en Química Biolóxica y Materiais Moleculares (CIQUS) and Facultade de Farmacia. Universidade de Santiago de Compostela, Santiago de compostela, 15782, Spain.
Institute for Medical Physics and Biophysics, Leipzig University, Leipzig, 04109, Germany.
Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen, Kobenhavn, 2200, Denmark.
The Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, U.K.
Laboratory of Neuroendocrinology-Molecular Cell Physiology, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Ljubljana, 1000, Slovenia.
Laboratory of Cell Engineering, Celica Biomedical, Ljubljana, 1000, Slovenia.
Department of Pharmaceutical Chemistry, Philipps-University Marburg, Marburg, 35039, Germany.

G protein-coupled receptors (GPCRs) are intensively studied due to their therapeutic potential as drug targets. Members of this large family of transmembrane receptor proteins mediate signal transduction in diverse cell types and play key roles in human physiology and health. In 2013 the research consortium GLISTEN (COST Action CM1207) was founded with the goal of harnessing the substantial growth in knowledge of GPCR structure and dynamics to push forward the development of molecular modulators of GPCR function. The success of GLISTEN, coupled with new findings and paradigm shifts in the field, led in 2019 to the creation of a related consortium called ERNEST (COST Action CA18133). ERNEST broadens focus to entire signaling cascades, based on emerging ideas of how complexity and specificity in signal transduction are not determined by receptor-ligand interactions alone. A holistic approach that unites the diverse data and perspectives of the research community into a single multidimensional map holds great promise for improved drug design and therapeutic targeting.

中文翻译：

欧洲信号转导研究网络（ERNEST）：对G蛋白偶联受体信号的多维整体理解。

由于G蛋白偶联受体（GPCR）作为药物靶标的治疗潜力，因此已得到深入研究。这个跨膜受体蛋白大家族的成员在多种细胞类型中介导信号转导，并在人类生理和健康中发挥关键作用。2013年成立了研究联盟GLISTEN（成本行动CM1207），旨在利用对GPCR结构和动力学的认识的显着增长来推动GPCR功能分子调节剂的发展。GLISTEN的成功，再加上该领域的新发现和范例转变，导致在2019年成立了一个名为ERNEST的相关财团（COST Action CA18133）。ERNEST将重点扩大到整个信号级联，基于新兴的想法，即信号转导的复杂性和特异性如何不仅仅由受体-配体相互作用决定。将研究社区的各种数据和观点整合为一个多维图的整体方法，对于改善药物设计和治疗目标具有广阔的前景。

更新日期：2020-04-23

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