CuBr-Catalyzed α-Arylation and Aerobic Oxidative Dehydrogenative C–N Coupling for the Synthesis of Spiro[cyclohexane-1,12′-isoindolo[1,2-b]quinazolin]-10′-one Derivatives,Organic Letters

当前位置： X-MOL 学术 › Org. Lett. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

CuBr-Catalyzed α-Arylation and Aerobic Oxidative Dehydrogenative C–N Coupling for the Synthesis of Spiro[cyclohexane-1,12′-isoindolo[1,2-b]quinazolin]-10′-one Derivatives
Organic Letters ( IF 4.9 ) Pub Date : 2020-03-31 , DOI: 10.1021/acs.orglett.0c00497
Fang Dong ₁ , Jian-Quan Liu ₁ , Xiang-Shan Wang ₁

Affiliation

A copper-catalyzed approach was disclosed for C(sp³)–C(sp²) bond formation via an α-arylation of carbonyl, and the subsequent oxidative dehydrogenation coupling occurred to form a C(sp³)–N bond, wherein O₂ served as a green oxidant. This protocol provided a domino method for the synthesis of spiro[cyclohexane-1,12′-isoindolo[1,2-b]quinazolin]-10′-ones containing a nitrogen-substituted quaternary carbon center.

中文翻译：

CuBr催化α-芳基化和好氧氧化脱氢CN键合成螺[环己烷-1,12'-异吲哚[1,2- b ]喹唑啉] -10'-一衍生物

公开了通过羰基的α-芳基化形成C（sp ³）-C（sp ²）键的铜催化方法，随后发生的氧化脱氢偶联反应形成了C（sp ³）-N键，其中O ₂用作绿色氧化剂。该方案提供了一种用于合成含有氮取代的季碳中心的螺[环己烷-1,12'-异吲哚并[1,2- b ]喹唑啉] -10'-的多米诺骨牌方法。

更新日期：2020-04-24

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11