In recent years, the emergence of single‐cell omics technologies, which can profile genomics, transcriptomics, epigenomics, and proteomics, has provided unprecedented insights into characteristics of cancer, enabling higher resolution and accuracy to decipher the cellular and molecular mechanisms relating to tumorigenesis, evolution, metastasis, and immune responses. Single‐cell multi‐omics technologies, which are developed based on the combination of multiple single‐cell mono‐omics technologies, can simultaneously analyze RNA expression, single nucleotide polymorphism, epigenetic modification, or protein abundance, enabling the in‐depth understanding of gene expression regulatory mechanisms. In this review, the state‐of‐the‐art single‐cell multi‐omics technologies are summarized and the prospects of their application in cancer biology are discussed.

中文翻译：

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单细胞多组学及其在癌症生物学中的前瞻性应用。

近年来，单细胞组学技术的出现，可以分析基因组学、转录组学、表观基因组学和蛋白质组学，为癌症特征提供了前所未有的洞察力，能够以更高的分辨率和准确性破译与肿瘤发生相关的细胞和分子机制，进化、转移和免疫反应。单细胞多组学技术，是在多种单细胞单组学技术组合的基础上发展起来的，可以同时分析RNA表达、单核苷酸多态性、表观遗传修饰或蛋白质丰度，从而深入了解基因表达调控机制。在这次审查中，