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Monomeric Flavanols Are More Efficient Substrates for Gut Microbiota Conversion to Hydroxyphenyl-γ-Valerolactone Metabolites Than Oligomeric Procyanidins: A Randomized, Placebo-Controlled Human Intervention Trial.
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2020-04-20 , DOI: 10.1002/mnfr.201901135
Wendy J Hollands 1 , Mark Philo 1 , Natalia Perez-Moral 1 , Paul W Needs 1 , George M Savva 2 , Paul A Kroon 1
Affiliation  

The majority of ingested flavanols reach the colon where they are catabolized by the microbiota to form hydroxyphenyl‐γ‐valerolactones (HGVLs). It is not known if the HGVLs are catabolic products of monomeric (epi)catechins (EPC), oligomeric procyanidins (OPCs), or both. Using data from a randomized, double‐blind, placebo‐controlled crossover trial the relative contributions of catechins and OPC to the bioavailable pool of HGVLs are estimated.

中文翻译:


与低聚原花青素相比,单体黄烷醇是肠道微生物群转化为羟苯基-γ-戊内酯代谢物更有效的底物:一项随机、安慰剂对照的人体干预试验。



大多数摄入的黄烷醇到达结肠,在那里被微生物群分解代谢形成羟苯基-γ-戊内酯(HGVL)。目前尚不清楚 HGVL 是否是单体(表)儿茶素 (EPC)、低聚原花青素 (OPC) 或两者的分解代谢产物。使用随机、双盲、安慰剂对照交叉试验的数据,估计了儿茶素和 OPC 对 HGVL 生物利用度库的相对贡献。
更新日期:2020-04-20
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