Nanoemulsions of Acai Oil: Physicochemical Characterization for the Topical Delivery of Antifungal Drugs,Chemical Engineering & Technology

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Nanoemulsions of Acai Oil: Physicochemical Characterization for the Topical Delivery of Antifungal Drugs
Chemical Engineering & Technology ( IF 1.8 ) Pub Date : 2020-04-23 , DOI: 10.1002/ceat.201900627
Denise Maria Loureiro Contente ₁ , Rayanne Rocha Pereira ₁ , Antonio Manoel Cruz Rodrigues ₂ , Edilene Oliveira da Silva _{3,

4} , Roseane Maria Ribeiro-Costa ₅ , José Otavio Carrera Silva-Júnior ₁

Affiliation

Nanoemulsion‐based acai oil was obtained by the phase inversion method using two nonionic surfactants, Ceteareth‐20 (Brij™ CS20) and polyoxyethylene‐hydrogenated castor oil (Croduret™ 50), with the concentration of each surfactant varying from 7 to 10 %. The formulation with 10 % Brij CS20 presented the best values for droplet size, zeta potential, and polydispersity index (PDI). Ketoconazole was incorporated into this formulation, with an encapsulation efficiency of 98.31 % and equally good zeta potential, droplet size, and PDI, and spherical shape when observed by transmission electron microscopy. Overall, nanoemulsions of acai oil proved to be a good vehicle for imidazole antifungals such as ketoconazole.

中文翻译：

Acai油的纳米乳剂：局部递送抗真菌药物的理化特性

使用两种非离子型表面活性剂Ceteareth-20（Brij™CS20）和聚氧乙烯氢化蓖麻油（Croduret™50），通过相转化法获得基于纳米乳液的巴西莓油，每种表面活性剂的浓度范围为7％至10％。含10％Brij CS20的配方呈现出最佳的液滴尺寸，ζ电位和多分散指数（PDI）值。当通过透射电子显微镜观察时，将酮康唑掺入该制剂中，其包封效率为98.31％，ζ电势，液滴尺寸和PDI均良好，球形。总体而言，阿拉伯树胶油的纳米乳被证明是咪唑类抗真菌药（如酮康唑）的良好载体。

更新日期：2020-04-23

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