The present study pertains to a polar organic chemical integrative sampler (POCIS) laboratory calibration to estimate the sampling rates for 44 pharmaceuticals featuring a wide range of polarity (-0.6 < octanol/water partition coefficient [log KOW ] < 5.4). The calibration was performed at 16.0 ± 1.5 °C for 4 water flow velocities (0, 2-3, 6-7, and 20 cm/s) in both a tank (for calibration at 0 cm/s) and a laboratory-scale artificial river filled with 200 and 500 L of tap water spiked with 0.3 µg/L of each compound, respectively. Twelve new sampling rates and 26 sampling rates already available in the literature were determined, whereas the sampling rates for 6 pharmaceuticals could not be determined due to nonlinearity or poor accumulation in POCIS. An increase in the sampling rate value with flow velocity was observed, which is consistent with a decrease in the effective thickness of the water boundary layer at the POCIS membrane surface. Environ Toxicol Chem 2020;39:1186-1195. © 2020 SETAC.

中文翻译：

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不同流量条件下在人工河中44种药物极性有机化学综合采样器的采样率的实验估算。

本研究涉及极性有机化学综合采样器（POCIS）实验室校准，以估计具有广泛极性（-0.6 <辛醇/水分配系数[log KOW] <5.4）的44种药物的采样率。在16.0±1.5°C的水箱（用于0 cm / s的校准）和实验室规模的4种水流速度（0、2-3、6-7和20 cm / s）下进行校准在装有200和500 L自来水的人工河中，每种水分别加标0.3μg/ L。确定了十二种新的采样率和文献中已有的26种采样率，而由于POCIS的非线性或积累不足，无法确定6种药物的采样率。观察到采样率值随流速增加，这与POCIS膜表面水边界层有效厚度减小是一致的。Environ Toxicol Chem 2020; 39：1186-1195。©2020 SETAC。