Acute Phase Response as a Biological Mechanism-of-Action of (Nano)particle-Induced Cardiovascular Disease.,Small

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Acute Phase Response as a Biological Mechanism-of-Action of (Nano)particle-Induced Cardiovascular Disease.
Small ( IF 13.0 ) Pub Date : 2020-03-29 , DOI: 10.1002/smll.201907476
Niels Hadrup ₁ , Vadim Zhernovkov ₂ , Nicklas Raun Jacobsen ₁ , Carola Voss ₃ , Maximilian Strunz ₃ , Meshal Ansari ₃ , Herbert B Schiller ₃ , Sabina Halappanavar ₄ , Sarah S Poulsen ₁ , Boris Kholodenko ₂ , Tobias Stoeger ₃ , Anne Thoustrup Saber ₁ , Ulla Vogel _{1,

5}

Affiliation

Inhaled nanoparticles constitute a potential health hazard due to their size-dependent lung deposition and large surface to mass ratio. Exposure to high levels contributes to the risk of developing respiratory and cardiovascular diseases, as well as of lung cancer. Particle-induced acute phase response may be an important mechanism of action of particle-induced cardiovascular disease. Here, the authors review new important scientific evidence showing causal relationships between inhalation of particle and nanomaterials, induction of acute phase response, and risk of cardiovascular disease. Particle-induced acute phase response provides a means for risk assessment of particle-induced cardiovascular disease and underscores cardiovascular disease as an occupational disease.

中文翻译：

急性阶段反应作为（纳米）颗粒诱发的心血管疾病的生物作用机制。

吸入的纳米颗粒由于其尺寸依赖性的肺部沉积和较大的表面质量比而构成潜在的健康危害。暴露于高水平会增加患上呼吸道和心血管疾病以及肺癌的风险。颗粒诱导的急性期反应可能是颗粒诱导的心血管疾病的重要作用机制。在这里，作者回顾了新的重要科学证据，这些证据显示了吸入颗粒和纳米材料，诱发急性期反应和心血管疾病的风险之间存在因果关系。颗粒物诱发的急性期反应为评估颗粒物诱发的心血管疾病提供了一种手段，并强调了心血管疾病是一种职业病。

更新日期：2020-03-29

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