Understanding Substrate Selectivity of Phoslactomycin Polyketide Synthase by Using Reconstituted in Vitro Systems.,ChemBioChem

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Understanding Substrate Selectivity of Phoslactomycin Polyketide Synthase by Using Reconstituted in Vitro Systems.
ChemBioChem ( IF 2.6 ) Pub Date : 2020-03-30 , DOI: 10.1002/cbic.202000112
Kyra Geyer ₁ , Srividhya Sundaram ₁ , Peter Sušnik ₂ , Ulrich Koert ₂ , Tobias J Erb _{1,

3}

Affiliation

Going to any length : Polyketide synthases produce compounds of high structural and functional diversity. We have created phoslactomycin polyketide synthase‐derived in vitro systems and studied their substrate selectivity. We were able to produce various phoslactomycin derivatives with altered side‐chain lengths and characterized the transacylation and hydrolysis activity of the involved acyltransferases for all substrates tested.

中文翻译：

通过使用体外系统重构了解磷脂酰聚酮合酶的底物选择性。

长度不限：聚酮化合物合酶可产生具有高度结构和功能多样性的化合物。我们创建了源自磷脂球菌聚酮合酶的体外系统，并研究了其底物选择性。我们能够生产出具有改变的侧链长度的各种磷霉素衍生物，并针对所有测试的底物表征了所涉及的酰基转移酶的转酰基作用和水解活性。

更新日期：2020-03-30

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