Nanosheet-assembled carbonated hydroxyapatite microspheres prepared by an EDTA-assisted hydrothermal homogeneous precipitation route,CrystEngComm

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Nanosheet-assembled carbonated hydroxyapatite microspheres prepared by an EDTA-assisted hydrothermal homogeneous precipitation route
CrystEngComm ( IF 2.6 ) Pub Date : 2020-03-30 , DOI: 10.1039/d0ce00305k
Mei-li Qi _{1,

2,

3,

4,

5} , Shengkun Yao _{4,

6,

7,

8,

9} , Xiao-Cun Liu _{1,

2,

3,

4} , Xiaoning Wang _{1,

2,

3,

4} , Fengkun Cui _{1,

2,

3,

4}

Affiliation

Carbonated hydroxyapatite (CHA) microspheres assembled from nanosheets were synthesized using disodium ethylene diamine tetraacetate (Na₂EDTA) as the chelating agent and urea as the pH regulator. By adjusting the hydrothermal treatment temperature and time, the morphologies and three-dimensional architectures of the CHA products were well controlled. The phase, morphology, and particle size distribution of the as-synthesized microspheres were characterized by X-ray diffraction, scanning electron microscopy and laser diffraction particle size analysis. Results show that relatively high reaction temperatures could promote the formation of microspheres. The spherical structures were transformed from sparse to dense with prolonged reaction time. Well-rounded CHA microspheres with a mean diameter of ∼30 μm can be produced at 180 °C for 10 h. The underlying mechanism for the formation of CHA microspheres in the presence of Na₂EDTA under hydrothermal homogeneous precipitation conditions was proposed. Flower-like CHA crystals formed, gathered continuously and finally grew into CHA microspheres with increased temperature and prolonged reaction time. This study provides an easy way to obtain well-rounded CHA microspheres with a relatively large size for biomedical applications.

中文翻译：

EDTA辅助水热均相沉淀法制备纳米片状碳酸羟基磷灰石微球

使用乙二胺二乙酸二钠（Na _2）合成由纳米片组装而成的碳酸羟基磷灰石（CHA）微球EDTA）作为螯合剂，尿素作为pH调节剂。通过调节水热处理温度和时间，可以很好地控制CHA产品的形貌和三维结构。通过X射线衍射，扫描电子显微镜和激光衍射粒度分析表征了所合成的微球的相，形态和粒度分布。结果表明，较高的反应温度可以促进微球的形成。球形结构从稀疏转变为致密，并延长了反应时间。可以在180°C的温度下连续10小时生产出平均直径约为30μm的圆形的CHA微球。Na ₂存在下CHA微球形成的潜在机理提出了在水热均匀沉淀条件下的EDTA。花状CHA晶体形成，连续聚集并最终长成温度升高，反应时间延长的CHA微球。这项研究提供了一种简单的方法来获取具有相对较大尺寸的，用于生物医学应用的全面的CHA微球。

更新日期：2020-03-30

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