Escaping programmed cell death is a hallmark of cancer. NF-κB transcription factors are key regulator of cell survival and aberrant NF-κB signaling has been involved in the pathogenesis of most human malignancies. Although NF-κB is best known for its antiapoptotic role, other processes regulating the life/death balance, such as autophagy and necroptosis, seem to network with NF-κB. This review discusses how the reciprocal regulation of NF-κB, autophagy and programmed cell death affect cancer development and progression.

中文翻译：

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癌症的生命，死亡和自噬：NF-κB随处可见

避免程序性细胞死亡是癌症的标志。NF-κB转录因子是细胞存活的关键调节因子，NF-κB异常信号已参与大多数人类恶性肿瘤的发病机制。尽管NF-κB以其抗凋亡作用而闻名，但其他调节生活/死亡平衡的过程，例如自噬和坏死病似乎与NF-κB形成网络。这篇综述讨论了NF-κB，自噬和程序性细胞死亡的相互调节如何影响癌症的发展和进程。