Cancer stemness in hepatocellular carcinoma: mechanisms and translational potential.,British Journal of Cancer

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Cancer stemness in hepatocellular carcinoma: mechanisms and translational potential.
British Journal of Cancer ( IF 6.4 ) Pub Date : 2020-03-31 , DOI: 10.1038/s41416-020-0823-9
Yu-Man Tsui _{1,

2} , Lo-Kong Chan _{1,

2} , Irene Oi-Lin Ng _{1,

2}

Affiliation

Cancer stemness, referring to the stem-cell-like phenotype of cancer cells, has been recognised to play important roles in different aspects of hepatocarcinogenesis. A number of well-established cell-surface markers already exist for liver cancer stem cells, with potential new markers of liver cancer stem cells being identified. Both genetic and epigenetic factors that affect various signalling pathways are known to contribute to cancer stemness. In addition, the tumour microenvironment-both physical and cellular-is known to play an important role in regulating cancer stemness, and the potential interaction between cancer stem cells and their microenvironment has provided insight into the regulation of the tumour-initiating ability as well as the cellular plasticity of liver CSCs. Potential specific therapeutic targeting of liver cancer stemness is also discussed. With increased knowledge, effective druggable targets might be identified, with the aim of improving treatment outcome by reducing chemoresistance.

中文翻译：

肝细胞癌中的癌症干性：机制和转化潜力。

癌症干性是指癌细胞的干细胞样表型，已被认为在肝癌发生的不同方面发挥重要作用。肝癌干细胞已经存在许多成熟的细胞表面标志物，并且正在鉴定潜在的肝癌干细胞新标志物。已知影响各种信号通路的遗传和表观遗传因素都有助于癌症干性。此外，已知肿瘤微环境（物理的和细胞的）在调节癌症干细胞中发挥重要作用，癌症干细胞与其微环境之间的潜在相互作用为了解肿瘤启动能力的调节以及肝脏 CSCs 的细胞可塑性。还讨论了肝癌干性的潜在特异性治疗靶向。随着知识的增加，可以确定有效的药物靶点，目的是通过减少化学抗性来改善治疗结果。

更新日期：2020-04-24

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