Chromatin replication and epigenetic cell memory.,Nature Cell Biology

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Chromatin replication and epigenetic cell memory.
Nature Cell Biology ( IF 17.3 ) Pub Date : 2020-03-30 , DOI: 10.1038/s41556-020-0487-y
Kathleen R Stewart-Morgan _{1,

2} , Nataliya Petryk _{2,

3} , Anja Groth _{1,

2}

Affiliation

Propagation of the chromatin landscape across cell divisions is central to epigenetic cell memory. Mechanistic analysis of the interplay between DNA replication, the cell cycle, and the epigenome has provided insights into replication-coupled chromatin assembly and post-replicative chromatin maintenance. These breakthroughs are critical for defining how proliferation impacts the epigenome during cell identity changes in development and disease. Here we review these findings in the broader context of epigenetic inheritance across mitotic cell division.

中文翻译：

染色质复制和表观遗传细胞记忆。

染色质分布跨细胞分裂的传播是表观遗传细胞记忆的核心。DNA复制，细胞周期和表观基因组之间相互作用的机理分析为复制耦合染色质组装和复制后染色质维持提供了见识。这些突破对于定义在发育和疾病中细胞身份变化期间增殖如何影响表观基因组至关重要。在这里，我们在有丝分裂细胞分裂的表观遗传的更广泛背景下回顾了这些发现。

更新日期：2020-04-24

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