Post-translational histone modifications are important regulators of nuclear reprogramming. A study now reveals that histone lysine demethylase KDM4A-mediated H3K9me3 demethylation in mammalian oocytes is essential for zygotic genome activation and preimplantation development.

中文翻译：

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设置卵母细胞的染色质阶段

翻译后的组蛋白修饰是核重编程的重要调节剂。现在的一项研究表明，哺乳动物卵母细胞中组蛋白赖氨酸脱甲基酶KDM4A介导的H3K9me3脱甲基对于合子基因组激活和植入前发育至关重要。