Purpose

To compare the outcomes of Sinonasal Mucosal Melanomas (SNMM) treated with endoscopic and open resection.

Methods

A retrospective case review of 20 patients with SNMM treated surgically at UCSF. Kaplan–Meier analyses were calculated to determine outcome differences in endoscopic vs. open resections.

Results

From 2005 to 2014, 20 cases of SNMM were confirmed and treated at UCSF. All cases underwent surgical resection, with 10 cases by open resection and 10 cases by endoscopic resection. Using Kaplan–Meier analyses, the open resection group had a 1-year survival of 30% whereas endoscopic resection group was 80% (p = 0.032). Endoscopic resection showed improved survival at all time points after surgery compared to open resection.

Conclusion

SNMM is a rare and aggressive tumor that is associated with low survival rates. In this small case series, endoscopic resection had improved survival outcomes compared to open resection.

中文翻译：

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鼻腔鼻腔黏膜黑色素瘤内镜和开放切除的结果：一项回顾性队列研究

目的

比较内镜和开放切除术治疗鼻腔鼻腔黏膜黑色素瘤（SNMM）的结果。

方法

在 UCSF 接受手术治疗的 20 名 SNMM 患者的回顾性病例回顾。计算 Kaplan-Meier 分析以确定内镜与开放切除术的结果差异。

结果

从 2005 年到 2014 年，加州大学旧金山分校确诊和治疗了 20 例 SNMM。所有病例均行手术切除，其中开放性切除10例，内镜切除10例。使用 Kaplan-Meier 分析，开放切除组的 1 年生存率为 30%，而内镜切除组为 80%（p = 0.032）。与开放性切除术相比，内镜下切除术在手术后的所有时间点均显示出更高的生存率。

结论

SNMM 是一种罕见的侵袭性肿瘤，与低存活率相关。在这个小型病例系列中，与开放切除术相比，内镜切除术提高了生存率。