Influenza A viruses (IAVs) are highly contagious pathogens infecting human and numerous animals. The viruses cause millions of infection cases and thousands of deaths every year, thus making IAVs a continual threat to global health. Upon IAV infection, host innate immune system is triggered and activated to restrict virus replication and clear pathogens. Subsequently, host adaptive immunity is involved in specific virus clearance. On the other hand, to achieve a successful infection, IAVs also apply multiple strategies to avoid be detected and eliminated by the host immunity. In the current review, we present a general description on recent work regarding different host cells and molecules facilitating antiviral defenses against IAV infection and how IAVs antagonize host immune responses.

中文翻译：

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宿主病毒相互作用：宿主细胞如何防御甲型流感病毒感染。

甲型流感病毒（IAV）是高度传染性的病原体，可感染人类和众多动物。病毒每年导致数百万例感染病例，成千上万的死亡，因此使IAV持续威胁着全球健康。IAV感染后，宿主先天免疫系统被触发并激活，以限制病毒复制并清除病原体。随后，宿主适应性免疫与特定病毒清除有关。另一方面，为了获得成功的感染，IAV还采用了多种策略来避免被宿主免疫力检测和消除。在当前的审查中，我们目前对有关不同宿主细胞和分子促进针对IAV感染的抗病毒防御以及IAV如何拮抗宿主免疫反应的最新研究进行了概述。