The Bis(2-ethylhexyl)phthalate (DEHP), a widespread plasticizer, is considered an endocrine disrupting chemical with main toxicological effects on reproductive and metabolic systems. Human biomonitoring (HBM) studies are promoted to evaluate the background exposure levels. In the frame of LIFE PERSUADED project, the HBM study measured DEHP main metabolites (mono-(2-ethylhexyl) phthalate, MEHP; 2-ethyl-5-hydroxy-hexylphthalate, MEHHP; 2-ethyl-5-oxo-hexylphthalate, MEOHP) in Italian children and adolescent (4-14 years old) according to geographical macro-areas and areas, age and sex. Children from the South and the Centre of Italy showed higher median levels of DEHP, as a sum of its metabolites (48.14 and 47.80 μg/L), than those from the North (39.47 μg/L; p = 0.0090 and 0.0004, respectively). Considering the total population, boys are more exposed than girls (only as urinary volume), and children aged 4-6 years have higher median levels than those 7-10 and 11-14 years old. The derived reference values (RV95) for DEHP in children is 168 μg/L. The relative metabolic rates of DEHP, the background levels and, thus, the RV95, vary with the geographical area, age and sex, indicating that all these parameters should be considered in the risk assessment.

中文翻译：

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意大利儿童和青少年中邻苯二甲酸二（2-乙基己基）酯（DEHP）的生物监测：来自LIFE PERSUADED项目的数据。

邻苯二甲酸双（2-乙基己基）酯（DEHP）是一种广泛的增塑剂，被认为是一种破坏内分泌的化学物质，对生殖和代谢系统具有主要的毒理作用。促进人体生物监测（HBM）研究以评估背景暴露水平。在LIFE PERSUADED项目的框架内，HBM研究测量了DEHP的主要代谢物（邻苯二甲酸单-（2-乙基己基）MEME；邻苯二甲酸2-乙基-5-羟基己酯； MEHHP；邻苯二甲酸2-乙基-5-氧杂己酯； MEOHP ）在意大利儿童和青少年（4-14岁）中，根据地理区域和地区，年龄和性别划分。来自南部和意大利中部的儿童代谢产物之和的DEHP中位数水平较高（分别为48.14和47.80μg/ L），高于北部的儿童（39.47μg/ L； p = 0.0090和0.0004） 。考虑到总人口，男孩比女孩暴露更多（仅作为尿量），并且4-6岁的孩子的中位水平高于7-10和11-14岁的孩子。儿童中DEHP的参考值（RV95）为168μg/ L。DEHP的相对代谢率，背景水平以及RV95随地理区域，年龄和性别的不同而变化，这表明在风险评估中应考虑所有这些参数。