Apoptosis is a form of programmed cell death, deregulation of which occurs in multiple disorders, including neurodegenerative and autoimmune diseases as well as cancer. The formation of a death-inducing signaling complex (DISC) and death effector domain (DED) filaments are critical for initiation of the extrinsic apoptotic pathway. Post-translational modifications (PTMs) of DED-containing DISC components such as FADD, procaspase-8, and c-FLIP comprise an additional level of apoptosis regulation, which is necessary to overcome the threshold for apoptosis induction. In this review we discuss the influence of PTMs of FADD, procaspase-8, and c-FLIP on DED filament assembly and cell death induction, with a focus on the 3D organization of the DED filament.

中文翻译：

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通过DED蛋白的翻译后修饰控制细胞死亡。

凋亡是程序性细胞死亡的一种形式，其失调发生在多种疾病中，包括神经退行性疾病和自身免疫性疾病以及癌症。诱导死亡的信号复合物（DISC）和死亡效应域（DED）细丝的形成对于外源性凋亡途径的启动至关重要。包含DED的DISC组件（例如FADD，procaspase-8和c-FLIP）的翻译后修饰（PTM）包含额外的凋亡调控水平，这对于克服凋亡诱导阈值是必需的。在这篇综述中，我们讨论了FADD，procaspase-8和c-FLIP的PTM对DED细丝组装和细胞死亡诱导的影响，重点是DED细丝的3D组织。