Although efforts have been made to develop therapeutic approaches, the clinical management of AD maintains a major challenge. CircRNAs are highly abundant and evolutionarily conserved in neuronal tissues in mammals. Accumulating data suggest that circRNAs regulate biological and pathological processes by sponging miRNAs, binding to RBPs, modulating mRNA stability, and being translated into peptides in various diseases, serving as biomarkers and potential therapeutic targets. Growing evidence demonstrates that circRNAs have been implicated in the pathogenesis of AD. Here, we summarized current studies on circRNAs involved in AD pathology, providing a theoretical basis for the use of circRNAs in AD treatment and diagnosis.

尽管已经努力开发治疗方法，但是AD的临床管理仍然是主要挑战。CircRNA在哺乳动物的神经元组织中高度丰富且在进化上保守。越来越多的数据表明，circRNA通过使miRNA变海绵，与RBP结合，调节mRNA的稳定性，并在各种疾病中被翻译成肽，从而调控生物和病理过程，从而成为生物标志物和潜在的治疗靶标。越来越多的证据表明，circRNA与AD的发病机制有关。在这里，我们总结了目前有关circRNA参与AD病理的研究，为circRNA在AD治疗和诊断中的应用提供了理论基础。