Abstract We proposed a depth-intensity curve discrimination (DCD) method for assessing absorbed dose contributions of hydroxyl radicals (HO·) due to thermal neutrons, fast neutrons, and gamma rays in accelerator-based mixed radiation fields, that are relevant to boron neutron capture therapy (BNCT). The HO· yields of thermal neutrons, fast neutrons, and gamma-rays measured by coumarin-3-carboxylic acid solutions were discriminately evaluated using depth-intensity curves of their radiations and maximum likelihood-expectation maximization algorithm. The discrimination accuracies of the three types of radiation were 2.8%, 4.2%, and 1.0%, respectively. We demonstrated that the DCD method is appropriate to determine absorbed dose contributions of HO· in complex accelerator-based neutron fields for BNCT.

中文翻译：

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在基于加速器的中子场中区分由热中子、快中子和伽马射线引起的羟基自由基产率

摘要 我们提出了一种深度-强度曲线鉴别 (DCD) 方法，用于评估与硼中子相关的基于加速器的混合辐射场中由热中子、快中子和伽马射线引起的羟基自由基 (H2O·) 的吸收剂量贡献。捕获疗法（BNCT）。使用香豆素-3-羧酸溶液测量的热中子、快中子和伽马射线的H2O·产率分别使用其辐射的深度-强度曲线和最大似然-期望最大化算法进行了评估。三种辐射的鉴别精度分别为2.8%、4.2%和1.0%。我们证明了 DCD 方法适用于确定 BNCT 的基于加速器的复杂中子场中 H2O· 的吸收剂量贡献。