Rheumatoid arthritis (RA) and autoimmune thyroid disease (AITD) can occur in the same patient in the autoimmune polyglandular syndrome 2. The association of the two conditions has been recognized long-time ago and the prevalence of AITD in patients with RA and vice versa is well assessed. Geographical variation of AITD and related autoantibodies in RA patients is partly due to ethnic and environmental differences of the studied populations. The impacts of thyroid disorders on RA outcome and vice versa are still controversy. In both AITD and RA genetic susceptibility and environmental factors play a synergic role in the development of the diseases. In this review we aimed at investigating the association of AITD and thyroid autoantibodies with RA, the common pathogenic pathways, the correlation with RA disease activity, and influence of the treatment.

中文翻译：

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自身免疫性甲状腺疾病和类风湿关节炎：双向相互作用。

类风湿性关节炎（RA）和自身免疫性甲状腺疾病（AITD）可以在同一个患者中发生。自身免疫性多腺综合征2经过充分评估。RA患者中AITD和相关自身抗体的地理变异部分是由于研究人群的种族和环境差异所致。甲状腺疾病对RA结果的影响仍然存在争议，反之亦然。在AITD和RA中，遗传易感性和环境因素在疾病发展中起着协同作用。在这篇综述中，我们旨在研究AITD和甲状腺自身抗体与RA的关联，常见的致病途径，与RA疾病活性的相关性，