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Two new secondary metabolites, saccharochlorines A and B, from a marine bacterium Saccharomonospora sp. KCTC-19160.
Bioorganic & Medicinal Chemistry Letters ( IF 2.5 ) Pub Date : 2020-03-29 , DOI: 10.1016/j.bmcl.2020.127145 Tu Cam Le 1 , Nikita Katila 2 , Songhee Park 2 , Jihye Lee 3 , Inho Yang 4 , Hyukjae Choi 2 , Dong-Young Choi 2 , Sang-Jip Nam 5
Bioorganic & Medicinal Chemistry Letters ( IF 2.5 ) Pub Date : 2020-03-29 , DOI: 10.1016/j.bmcl.2020.127145 Tu Cam Le 1 , Nikita Katila 2 , Songhee Park 2 , Jihye Lee 3 , Inho Yang 4 , Hyukjae Choi 2 , Dong-Young Choi 2 , Sang-Jip Nam 5
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Two new chlorinated secondary metabolites, saccharochlorines A and B (1 and 2), were isolated from the saline cultivation of a marine-derived bacterium Saccharomonospora sp. (KCTC-19160). The chemical structures of the saccharochlorines were elucidated by 2D NMR and MS spectroscopic data. Saccharochlorines A and B (1 and 2) exhibit weak inhibition of β-secretase (BACE1) in biochemical inhibitory assay, but they induced the release of Aβ (1-40) and Aβ (1-42) in H4-APP neuroglial cells. This discrepancy might be derived from the differences between the cellular and sub-cellular environments or the epigenetic stimulation of BACE1 expression.
中文翻译：
来自海洋细菌Saccharomonospora sp。的两种新的次生代谢产物糖氯A和B。KCTC-19160。
从海洋来源的细菌Saccharomonospora sp。的盐水培养物中分离出两个新的氯化次生代谢产物，糖精A和B（1和2）。（KCTC-19160）。通过2D NMR和MS光谱数据阐明了糖精的化学结构。在生化抑制试验中，糖氯霉素A和B（1和2）对β-分泌酶（BACE1）的抑制作用较弱，但它们诱导了H4-APP神经胶质细胞中Aβ（1-40）和Aβ（1-42）的释放。这种差异可能源于细胞和亚细胞环境之间的差异或BACE1表达的表观遗传刺激。
更新日期：2020-04-20
中文翻译：
来自海洋细菌Saccharomonospora sp。的两种新的次生代谢产物糖氯A和B。KCTC-19160。
从海洋来源的细菌Saccharomonospora sp。的盐水培养物中分离出两个新的氯化次生代谢产物，糖精A和B（1和2）。（KCTC-19160）。通过2D NMR和MS光谱数据阐明了糖精的化学结构。在生化抑制试验中，糖氯霉素A和B（1和2）对β-分泌酶（BACE1）的抑制作用较弱，但它们诱导了H4-APP神经胶质细胞中Aβ（1-40）和Aβ（1-42）的释放。这种差异可能源于细胞和亚细胞环境之间的差异或BACE1表达的表观遗传刺激。
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