Hypolipidemic constituents from the aerial portion of Sibiraea angustata.,Bioorganic & Medicinal Chemistry Letters

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Hypolipidemic constituents from the aerial portion of Sibiraea angustata.
Bioorganic & Medicinal Chemistry Letters ( IF 2.5 ) Pub Date : 2020-03-29 , DOI: 10.1016/j.bmcl.2020.127161
Hongdong Liu ₁ , Ting Zhang ₂ , Piao Jiang ₁ , Weifeng Zhu ₃ , Songhua Yu ₁ , Yong Liu ₄ , Bin Li ₁ , Fei Li ₂

Affiliation

Two new monoterpene acylglucosides (1-2) and one new aromatic glycoside (3), together with five known compounds (4-8), were isolated from 95% ethanol extract of Sibiraea angustata. The structures of these compounds were characterized by 2D-NMR and mass spectrometry. Compounds were evaluated for their hypolipidemic activity using oleic acid-induced lipid accumulation in HepG2 cells. RT-PCR analysis revealed that compound 5 could decrease the expression level of fatty acid synthase (FASN). Lipidomics analysis indicated that compound 5 significantly decreased the levels of 11 lipids in oleic acid-induced lipid accumulation, including triglycerides (TG), diglycerides (DG), phosphatidylcholines (PC) and 1-acyl-sn-glycero-3-phosphocholines (lysoPC). These data demonstrated that terpene acylglucosides are the major active constituents in Sibiraea angustata.

中文翻译：

西伯利亚ira的空中部分的降脂成分。

从95％的西伯利亚ea（Sibiraea angustata）乙醇提取物中分离出两种新的单萜酰基葡糖苷（1-2）和一种新的芳香族糖苷（3），以及五种已知的化合物（4-8）。这些化合物的结构通过2D-NMR和质谱表征。使用油酸诱导的HepG2细胞中的脂质蓄积来评估化合物的降血脂活性。RT-PCR分析显示化合物5可降低脂肪酸合酶（FASN）的表达水平。脂质组学分析表明，化合物5显着降低了油酸诱导的脂质积聚中的11种脂质的水平，包括甘油三酸酯（TG），甘油二酸酯（DG），磷脂酰胆碱（PC）和1-酰基-sn-甘油-3-磷酸胆碱（lysoPC））。

更新日期：2020-04-20

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