A novel and efficient method for the synthesis of thieno[3,2-c]pyridinones have been developed. The synthetic strategy relies on the synthesis of halothiophene esters utilized as substrates for subsequent Sonogashira cross-coupling reactions. Hydrazinolysis of corresponding esters and following hydrazide-alkyne ring closure transformations resulted in target thienopyridinones in good yields. It is also shown that pure hydrazine monohydrate is required to facilitate the hydrazide formations.

中文翻译：

---

thienopyridinones的合成通过酰肼炔环化

已经开发了新颖且有效的合成噻吩并[3,2-c]吡啶酮的方法。合成策略依赖于卤代噻吩酯的合成，该卤代噻吩酯用作后续Sonogashira交叉偶联反应的底物。相应酯的水合肼解反应以及酰肼-炔烃的闭环转化产生了高产率的目标噻吩并吡啶酮。还表明需要纯一水合肼来促进酰肼的形成。