Artemilavanolides A (1) and B (2), two unprecedented sesquiterpenoids with 6-oxabicyclo[3.2.1]octane scaffold, as well as one known biogenetically related sesquiterpenoid, 11β,13-dihydrosantamarin (3), were isolated from the aerial parts of Artemisia lavandulaefolia. The structures and absolute configurations of 1 and 2 were characterized by analysis of HRESIMS, NMR spectroscopic, single crystal X-ray diffraction, and electronic circular dichroism (ECD) data. The plausible biogenetic pathway for 1 and 2 was also proposed. Compound 1 was found to enhance the neurite outgrowth of NGF-mediated PC12 cells at a concentration of 10 μM.

Artemilavanolides A（1）和B（2），两个前所未有倍半萜与-6-氧杂二环[3.2.1]辛烷的支架，以及一个公知的biogenetically相关倍半萜类，11 β，13-dihydrosantamarin（3），从该天线中分离薰衣草的部分。通过分析HRESIMS，NMR光谱，单晶X射线衍射和电子圆二色性（ECD）数据来表征1和2的结构和绝对构型。还提出了1和2的合理生物遗传途径。化合物1 发现以10μM的浓度增强NGF介导的PC12细胞的神经突生长。