Leontopodioside A, isolated from the whole plants of Leontopodium leontopodioides, possesses significant α-glucosidase inhibitory activity. In this work, we studied the total synthesis of leontopodioside A by two strategies for the first time. The optimized strategy involved nine linear steps and has an overall yield of 16.1%. The key feature of the strategy is that glycosylation of chalcone acceptor first followed by the cyclization to construct the flavone scaffold, which has general applicability for the synthesis of flavonoid glycosides.

中文翻译：

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Leontopodioside A的全合成

从Leontopodium leontopodioides的整个植物中分离出来的Leontopodioside A具有显着的α-葡萄糖苷酶抑制活性。在这项工作中，我们首次通过两种策略研究了Leontopodioside A的总合成。优化策略涉及九个线性步骤，总产率为16.1％。该策略的关键特征是首先将查尔酮受体糖基化，然后环化以构建黄酮骨架，该骨架可用于合成类黄酮糖苷。