An atom-economic approach to synthesize 1,2,4-trisubstituted pyrroles through palladium-catalyzed imine-directed intramolecular C(sp³)H amination reaction has been developed. The imine group acts as a directing group as well as an intramolecular nucleophile for the first time in intramolecular CN bonds formation reactions.

中文翻译：

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通过C（sp ³）H活化形成Pd催化的亚胺定向分子内C N键：一种有效的多取代吡咯方法

已经开发了一种通过钯催化的亚胺定向分子内C（sp ³）H氨基化反应合成1,2,4-三取代的吡咯的原子经济方法。亚胺基团在分子内C N键形成反应中首次充当导向基团以及分子内亲核试剂。