Progressive supranuclear palsy (PSP) is a rare movement disorder with poor prognosis. This retrospective study aimed to characterize the natural history of PSP and to find predictors of shorter survival and faster decline of activity of daily living. All patients recruited fulfilled the movement disorder society (MDS) clinical diagnostic criteria for PSP (MDS-PSP criteria) for probable and possible PSP with median 12 years. Data were obtained including age, sex, date of onset, age at onset (AAO), symptoms reported at first visit and follow-up, date of death and date of institutionalization. Magnetic resonance imaging was collected at the first visit. Endpoints were death and institutionalization. Kaplan-Meier method and Cox proportional hazard model were used to explore factors associated with early death and institutionalization. Fifty-nine patients fulfilling MDS-PSP criteria were enrolled in our study. Nineteen patients (32.2%) had died and 31 patients (52.5%) were institutionalized by the end of the follow-up. Predictors associated with poorer survival were late-onset PSP and decreased M/P area ratio. Predictors associated with earlier institutionalization were older AAO and decreased M/P area ratio. Older AAO and decreased M/P area ratio were predictors for earlier dearth and institutionalization in PSP. The neuroimaging biomarker M/P area ratio was a predictor for prognosis in PSP.

中文翻译：

---

中脑/脑桥面积比和临床特征可预测进行性核上性麻痹的预后。

进行性核上性麻痹（PSP）是一种罕见的运动障碍，预后差。这项回顾性研究旨在描述PSP的自然史，并寻找生存期较短和日常生活活动下降较快的预测指标。招募的所有患者均符合PSP运动障碍协会（MDS）的临床诊断标准（MDS-PSP标准），其中位年龄为12岁，可能患有PSP。获得的数据包括年龄，性别，发病日期，发病年龄（AAO），首次就诊和随访时报告的症状，死亡日期和住院时间。第一次就诊时收集了磁共振成像。终点是死亡和机构化。Kaplan-Meier方法和Cox比例风险模型用于探讨与早期死亡和机构化相关的因素。符合MDS-PSP标准的59名患者参加了我们的研究。随访结束时，有19例患者（32.2％）死亡，31例患者（52.5％）已入院治疗。与较差生存率相关的预测因素是PSP迟发和M / P面积比降低。与早期机构化有关的预测因素是较老的AAO和降低的M / P面积比。较老的AAO和M / P面积比降低是PSP早期缺乏和机构化的预测因素。神经影像生物标志物M / P面积比是PSP预后的预测指标。与早期机构化有关的预测因素是较老的AAO和M / P面积比降低。较老的AAO和M / P面积比降低是PSP早期缺乏和机构化的预测因素。神经影像生物标志物M / P面积比是PSP预后的预测指标。与早期机构化有关的预测因素是较老的AAO和降低的M / P面积比。较老的AAO和M / P面积比降低是PSP早期缺乏和机构化的预测因素。神经影像生物标志物M / P面积比是PSP预后的预测指标。