Marmots are large Holarctic rodents with unique biological features, making them potential animal models in various research fields. Due to the rapid accumulation of the genetic data in marmots, a highly integrative database is urgent needed. iMarmot is freely available on the web at http://www.marmotdb.org/ and currently contains the biological information of 14 marmots, genomic sequence of 6 marmots, syntenic relationship and orthologs among 3 marmots, and expression profiles of several hibernators and plague hosts. To assist with the genomic and transcriptomic analysis, we also integrated a set of analysis and visualization tools, such as KEGG or GO enrichment analysis, PCA, Blast, Muscle, GeneWise, Lastz, and JBrowse. Particularly, one DEGs (differentially expressed genes) module has been implemented in this database to visualize the gene expression changes in hibernators and plague hosts. This database will provide comprehensive information and analysis platform for researchers interested in understanding the biological features of marmots.

中文翻译：

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iMarmot：土拨鼠比较基因组和功能基因组学的集成平台

土拨鼠是具有独特生物学特征的大型Holocctic啮齿动物，使其成为各个研究领域的潜在动物模型。由于土拨鼠中遗传数据的迅速积累，迫切需要一个高度集成的数据库。iMarmot可在http://www.marmotdb.org/上免费获取，目前包含14种土拨鼠的生物学信息，6种土拨鼠的基因组序列，3种土拨鼠之间的同系关系和直系同源物，以及数个冬眠者和鼠疫的表达谱主机。为了协助进行基因组和转录组分析，我们还集成了一组分析和可视化工具，例如KEGG或GO富集分析，PCA，Blast，Muscle，GeneWise，Lastz和JBrowse。尤其，该数据库中已实现一个DEG（差异表达基因）模块，以可视化冬眠者和鼠疫宿主中基因表达的变化。该数据库将为有兴趣了解土拨鼠生物学特性的研究人员提供全面的信息和分析平台。