Fatigue, sleep disturbance and altered mood are frequently reported in patients with primary antibody deficiency syndrome (PADS) on adequate immunoglobulin replacement therapy. This study aimed to determine the frequency of symptoms compatible with chronic fatigue syndrome (CFS) in patients with PADS. The study involved the distribution of 682 self-completed postal questionnaires to ascertain the presence and frequency of symptoms compatible with CFS in patients with PADS. The reporting of symptoms for each patient were scored against the CFS diagnostic criteria used within our own South London Chronic Fatigue service. The frequency of symptoms compatible with CFS were evident in 26 of the 188 patients (16.25%) returning adequately completed questionnaires. We considered a bias in the return of questionnaires amongst PADS patients with fatigue to be likely. As such we estimated the minimum frequency of CFS in patients with PADS to be 4% based on the 682 PAD patients to whom the questionnaire was distributed. This was significantly higher than the 0.5% estimate of the prevalence of CFS in the community in western populations. While the presence of significant fatigue correlated with the presence of anxiety and depression, there was no association with self-reported lung damage. Sleep disturbance affected 60% of the PAD patients returning satisfactory questionnaires and as expected the CFS score was higher in those with greater physical limitation. We conclude that patients with PADS have a high frequency of fatigue, low mood and anxiety. We suggest routine questioning for the symptoms of fatigue, disturbed sleep and altered mood in patients with PADS. The use of several treatment strategies in CFS may prove beneficial in improving the quality of life of patients with PAD.

中文翻译：

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原发性抗体缺乏症 (PAD) 和慢性疲劳综合征 (CFS) 中存在重叠的生活质量症状

原发性抗体缺乏综合征 (PADS) 患者在接受足够的免疫球蛋白替代治疗时经常报告疲劳、睡眠障碍和情绪改变。本研究旨在确定 PADS 患者与慢性疲劳综合征 (CFS) 相符的症状频率。该研究涉及分发 682 份自行填写的邮寄问卷，以确定 PADS 患者与 CFS 相符的症状的存在和频率。根据我们自己的南伦敦慢性疲劳服务中使用的 CFS 诊断标准对每位患者的症状报告进行评分。188 名患者中有 26 名（16.25%）返回了充分完成的问卷，符合 CFS 的症状频率很明显。我们认为在有疲劳的 PADS 患者中返回问卷时可能存在偏差。因此，根据向其分发问卷的 682 名 PAD 患者，我们估计 PADS 患者 CFS 的最低频率为 4%。这显着高于西方人群社区 CFS 患病率的 0.5% 估计值。虽然显着疲劳的存在与焦虑和抑郁的存在相关，但与自我报告的肺损伤无关。睡眠障碍影响了 60% 的 PAD 患者，他们返回了令人满意的问卷，并且正如预期的那样，身体限制较大的患者 CFS 评分较高。我们得出结论，PADS 患者出现频繁的疲劳、情绪低落和焦虑。我们建议对疲劳症状进行常规询问，PADS 患者的睡眠障碍和情绪改变。在 CFS 中使用几种治疗策略可能有助于改善 PAD 患者的生活质量。