Little is known about patient characteristics that contribute to initiating antiretroviral therapy (ART) and achieving viral suppression among HIV people with opioid use disorder in Vietnam. The primary objective of this analysis was to evaluate associations between participant characteristics and the critical steps in the HIV care continuum of ART initiation and HIV viral suppression among people with opioid use disorder and HIV in Vietnam. We assessed baseline participant characteristics, ART status, and HIV viral suppression (HIV RNA PCR < 200 copies/mL) enrolled in a clinical trial of HIV clinic-based buprenorphine versus referral for methadone among people with opioid use disorder in Vietnam. We developed logistic regression models to identify characteristics associated with ART status and HIV viral suppression. Among 283 study participants, 191 (67.5%) were prescribed ART at baseline, and 168 of those on ART (90%) were virally suppressed. Years since HIV diagnosis (aOR = 1.12, 95% CI 1.06, 1.19) and being married (aOR = 2.83, 95% CI 1.51, 5.34) were associated with an increased likelihood of current prescription for ART at baseline. Greater depression symptoms were negatively associated with receipt of ART (aOR = 0.97, 95% CI = (0.94, 0.9963)). In the HIV suppression model, once adjusting for all included covariates, only receipt of ART was associated with viral suppression (aOR = 25.9, 95% CI = (12.5, 53.8). In bivariate analyses, methamphetamine was negatively correlated with ART prescription (p = 0.07) and viral suppression (p = 0.08). While fewer than 90% of participants had received ART, 90% of those on ART had achieved HIV viral suppression at baseline, suggesting that interventions to improve uptake of ART in Vietnam are essential for achieving UNAIDS 90–90-90 goals in people who use heroin in Vietnam. Social determinants of health associated with ART and HIV viral suppression suggest that social support may be a key to facilitating both of these steps in the HIV care continuum.

中文翻译：

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越南阿片类药物使用障碍和 HIV 患者的 HIV 护理连续特征：BRAVO 研究的基线结果。

关于有助于在越南阿片类药物使用障碍的 HIV 患者中启动抗逆转录病毒治疗 (ART) 和实现病毒抑制的患者特征知之甚少。这项分析的主要目的是评估参与者特征与越南阿片类药物使用障碍和 HIV 患者的 ART 启动和 HIV 病毒抑制的 HIV 护理连续过程中的关键步骤之间的关联。我们评估了基线参与者特征、ART 状态和 HIV 病毒抑制（HIV RNA PCR < 200 拷贝/mL），该临床试验在越南阿片类药物使用障碍患者中参加了一项基于 HIV 诊所的丁丙诺啡与美沙酮转诊的临床试验。我们开发了逻辑回归模型来识别与 ART 状态和 HIV 病毒抑制相关的特征。在 283 名研究参与者中，191 名（67.5%）在基线时接受了 ART，168 名接受 ART 的人（90%）被病毒抑制。自 HIV 诊断 (aOR = 1.12, 95% CI 1.06, 1.19) 和已婚 (aOR = 2.83, 95% CI 1.51, 5.34) 以来的数年与基线时当前处方 ART 的可能性增加相关。更严重的抑郁症状与接受 ART 呈负相关（aOR = 0.97, 95% CI = (0.94, 0.9963)）。在 HIV 抑制模型中，一旦调整了所有包含的协变量，只有接受 ART 与病毒抑制相关（aOR = 25.9, 95% CI = (12.5, 53.8)。在双变量分析中，甲基苯丙胺与 ART 处方呈负相关（p = 0.07) 和病毒抑制 (p = 0.08)。虽然不到 90% 的参与者接受了 ART，接受 ART 的人中有 90% 在基线时实现了 HIV 病毒抑制，这表明在越南提高 ART 吸收的干预措施对于在越南使用海洛因的人中实现联合国艾滋病规划署的 90-90-90 目标至关重要。与 ART 和 HIV 病毒抑制相关的健康社会决定因素表明，社会支持可能是促进 HIV 护理连续体中这两个步骤的关键。