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Determination, Construction, and Evaluation of Ternary and Quaternary Solid–Liquid Phase Equilibrium of Uric Acid, Adenine, and Guanine in Water
Journal of Chemical & Engineering Data ( IF 2.0 ) Pub Date : 2020-03-30 , DOI: 10.1021/acs.jced.9b01207 Yang Cong 1 , Cunbin Du 1 , Meng Wang 1 , Zhouyu Jiang 1 , Tingting Ye 1 , Ying Zhang 1 , Bin Qiao 1 , Mingliang Wang 1
Journal of Chemical & Engineering Data ( IF 2.0 ) Pub Date : 2020-03-30 , DOI: 10.1021/acs.jced.9b01207 Yang Cong 1 , Cunbin Du 1 , Meng Wang 1 , Zhouyu Jiang 1 , Tingting Ye 1 , Ying Zhang 1 , Bin Qiao 1 , Mingliang Wang 1
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In this work, nine ternary phase diagrams and three quaternary phase diagrams of different systems at 298.15, 308.15, and 318.15 K were constructed. The ternary solid–liquid phase equilibrium of (uric acid + adenine + water), (uric acid + guanine + water), and (adenine + guanine + water) and quaternary solid–liquid phase equilibrium of (uric acid + adenine + guanine + water) were determined at atmospheric pressure (p = 101.3 kPa). The binary solubility of uric acid, adenine, and guanine in water at different temperatures was determined and correlated using the modified Apelblat model, and the mole solubility of adenine was about 30 and 180 times that of uric acid and guanine, respectively. The relative average deviation and root-mean-square deviation values were no more than 1.73 × 10–2 and 0.102 × 10–5, respectively. For a ternary system, each phase diagram consisted of one cosaturated point, two cosaturated solubility curves, and three solid-phase regions (two single solid-phase regions and one double solid-phase region). The mutual solubility of uric acid (adenine or guanine) in the systems of (uric acid + adenine + water), (uric acid + guanine + water), or (adenine + guanine + water) increased with increasing temperature. The unsaturated regions enlarged, and the single or double solid-phase regions diminished. For a quaternary system, each Janeck projection of the (uric acid + adenine + guanine + water) system consisted of one cosaturated point, three cosaturated solubility curves, and three solid-phase regions. At the same temperature, the solid-phase regions of three compounds were ranked as guanine > uric acid > adenine. The construction of binary, ternary, and quaternary phase diagrams of uric acid, adenine, and guanine in water was of great significance for studying the deposition of uric acid, and this can also provide reference and basic phase equilibrium data for further study of gout treatment and effects of uric acid on the cardiovascular system.
中文翻译：
水中尿酸，腺嘌呤和鸟嘌呤三元和四元固液平衡的测定，构建和评估
在这项工作中，构建了在298.15、308.15和318.15 K时不同系统的9个三元相图和3个四元相图。（尿酸+腺嘌呤+水），（尿酸+鸟嘌呤+水）和（腺嘌呤+鸟嘌呤+水）的三元固液相平衡和（尿酸+腺嘌呤+鸟嘌呤+在大气压（p = 101.3 kPa）下测定。使用改进的Apelblat模型确定并分析了在不同温度下尿酸，腺嘌呤和鸟嘌呤在水中的二元溶解度并建立了相关关系，腺嘌呤的摩尔溶解度分别约为尿酸和鸟嘌呤的30倍和180倍。相对平均偏差和均方根偏差值不超过1.73×10 –2和0.102×10 –5， 分别。对于三元系统，每个相图都由一个饱和点，两个饱和度溶解度曲线和三个固相区（两个单固相区和一个双固相区）组成。随着温度的升高，尿酸（腺嘌呤或鸟嘌呤）在（尿酸+腺嘌呤+水），（尿酸+鸟嘌呤+水）或（腺嘌呤+鸟嘌呤+水）体系中的互溶性增加。不饱和区域扩大，单或双固相区域减少。对于四元系统，（尿酸+腺嘌呤+鸟嘌呤+水）系统的每个Janeck投影都由一个饱和点，三个饱和溶解度曲线和三个固相区组成。在相同温度下，将三种化合物的固相区域排列为鸟嘌呤>尿酸>腺嘌呤。
更新日期：2020-04-24
中文翻译：
水中尿酸，腺嘌呤和鸟嘌呤三元和四元固液平衡的测定，构建和评估
在这项工作中，构建了在298.15、308.15和318.15 K时不同系统的9个三元相图和3个四元相图。（尿酸+腺嘌呤+水），（尿酸+鸟嘌呤+水）和（腺嘌呤+鸟嘌呤+水）的三元固液相平衡和（尿酸+腺嘌呤+鸟嘌呤+在大气压（p = 101.3 kPa）下测定。使用改进的Apelblat模型确定并分析了在不同温度下尿酸，腺嘌呤和鸟嘌呤在水中的二元溶解度并建立了相关关系，腺嘌呤的摩尔溶解度分别约为尿酸和鸟嘌呤的30倍和180倍。相对平均偏差和均方根偏差值不超过1.73×10 –2和0.102×10 –5， 分别。对于三元系统，每个相图都由一个饱和点，两个饱和度溶解度曲线和三个固相区（两个单固相区和一个双固相区）组成。随着温度的升高，尿酸（腺嘌呤或鸟嘌呤）在（尿酸+腺嘌呤+水），（尿酸+鸟嘌呤+水）或（腺嘌呤+鸟嘌呤+水）体系中的互溶性增加。不饱和区域扩大，单或双固相区域减少。对于四元系统，（尿酸+腺嘌呤+鸟嘌呤+水）系统的每个Janeck投影都由一个饱和点，三个饱和溶解度曲线和三个固相区组成。在相同温度下，将三种化合物的固相区域排列为鸟嘌呤>尿酸>腺嘌呤。
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