Summary

QuartataWeb is a user-friendly server developed for polypharmacological and chemogenomics analyses. Users can easily obtain information on experimentally verified (known) and computationally predicted (new) interactions between 5,494 drugs and 2,807 human proteins in DrugBank, and between 315,514 chemicals and 9,457 human proteins in the STITCH database. In addition, QuartataWeb links targets to KEGG pathways and GO annotations, completing the bridge from drugs/chemicals to function via protein targets and cellular pathways. It allows users to query a series of chemicals, drug combinations, or multiple targets, to enable multi-drug, multi-target, multi-pathway analyses, toward facilitating the design of polypharmacological treatments for complex diseases.

Availability and implementation

QuartataWeb is freely accessible at http://quartata.csb.pitt.edu.

Supplementary information

Supplementary dataSupplementary data are available at Bioinformatics online.

中文翻译：

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QuartataWeb：用于多药理学和化学基因组学的集成化学-蛋白质-途径映射。

概要

QuartataWeb是为多药理学和化学基因组学分析开发的用户友好服务器。用户可以轻松获得有关DrugBank中5,494种药物与2,807种人类蛋白质之间以及STITCH数据库中315,514种化学物质与9,457种人类蛋白质之间经过实验验证（已知）和计算预测（新）相互作用的信息。此外，QuartataWeb将靶标链接到KEGG途径和GO注释，从而完成了从药物/化学物质到蛋白质靶点和细胞途径的功能的桥梁。它允许用户查询一系列化学药品，药物组合或多个目标，以实现多药物，多目标，多途径分析，从而有助于设计复杂疾病的多药理学疗法。

可用性和实施

QuartataWeb可从http://quartata.csb.pitt.edu免费访问。

补充资料

补充数据补充数据可从Bioinformatics在线获得。