Demonstration of intrathecal production of Borrelia-specific antibodies (ITAb) is considered the most specific diagnostic marker of Lyme neuroborreliosis (LNB). Limitations include delayed detectability in early infection and continued presence long after successful treatment. Markers of active inflammation—increased cerebrospinal fluid (CSF) leukocytes, protein, and CXCL13—provide nonspecific markers of active infection. To assess the utility of CSF CXCL13, we measured its concentration in 132 patients with a broad spectrum of neuroinflammatory disorders, including LNB.

中文翻译：

---

脑脊液 CXCL13 在莱姆神经疏螺旋体病中的特异性和诊断效用

证明鞘内产生疏螺旋体特异性抗体 (ITAb) 被认为是莱姆神经疏螺旋体病 (LNB) 最特异性的诊断标志物。局限性包括早期感染的延迟检测和成功治疗后很长时间的持续存在。活动性炎症的标志物——脑脊液 (CSF) 白细胞、蛋白质和 CXCL13 增加——提供活动性感染的非特异性标志物。为了评估 CSF CXCL13 的效用，我们测量了 132 名患有广谱神经炎症性疾病（包括 LNB）的患者的浓度。