Hepatocellular carcinoma (HCC) is a common histological class of primary liver cancer with dismal prognosis. Long noncoding RNAs (lncRNAs) are increasingly documented as participators in cancers. Present study aimed to explore the role of long intergenic nonprotein-coding RNA 467 (LINC00467) in HCC. LINC00467 was upregulated in HCC samples in TCGA database, and was confirmed to be elevated in HCC cell lines. Functionally, LINC00467 depletion impeded proliferation and invasion, induced apoptosis, and promoted cellular sensitivity to Axitinib in HCC. Mechanistically, LINC00467 performed as a sponge of microRNA (miR)-509-3p and upregulated the expression of platelet-derived growth factor receptor alpha (PDGFRA) in HCC cells. In conclusion, our study illustrated that LINC00467 promoted proliferation and invasion, impedes apoptosis, and contributed to Axitinib resistance of hepatocellular carcinoma through miR-509-3p/PDGFRA, indicating LINC00467 as a promising biological target for HCC treatment.

肝细胞癌（HCC）是一种常见的组织学类型的原发性肝癌，预后不佳。长链非编码 RNA (lncRNA) 越来越多地被记录为癌症的参与者。本研究旨在探讨长基因间非蛋白编码 RNA 467 (LINC00467) 在 HCC 中的作用。LINC00467 在 TCGA 数据库的 HCC 样本中上调，并被证实在 HCC 细胞系中升高。在功能上，LINC00467 耗竭阻碍增殖和侵袭，诱导细胞凋亡，并促进 HCC 中细胞对阿西替尼的敏感性。从机制上讲，LINC00467 作为 microRNA (miR)-509-3p 海绵发挥作用，并上调 HCC 细胞中血小板衍生生长因子受体 α (PDGFRA) 的表达。总之，我们的研究表明 LINC00467 促进增殖和侵袭，阻碍细胞凋亡，