Glycals, 1,2-unsatrated carbohydrates, are versatile building blocks for the synthesis of various scaffolds. Despite their potential to serve as suitable precursors in diversity-oriented synthesis, 2-cyanoglycals are less explored in terms of their synthesis and derivatization. Herein, we report a combination of Ac2O and AcOH as new and efficient dehydrating agent of aldoximes for the synthesis of 2-cyanoglycals. In comparison to the conventional dehydrating system of Ac2O-base (such as NaOH, NaOAc and K2CO3), the current protocol provides superior yields and faster reaction rates. The scope and limitations of the dehydrating system are investigated.

中文翻译：

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乙酸酐-乙酸作为用于制备腈类的新型醛肟脱水剂：2-氰基的制备

Glycals 是一种 1,2-不饱和碳水化合物，是合成各种支架的通用构件。尽管它们有可能在面向多样性的合成中用作合适的前体，但在合成和衍生化方面对 2-氰基糖的探索较少。在此，我们报告了 Ac2O 和 AcOH 的组合作为用于合成 2-氰基的新型高效醛肟脱水剂。与传统的 Ac2O 碱脱水系统（如 NaOH、NaOAc 和 K2CO3）相比，当前的协议提供了更高的产量和更快的反应速率。研究了脱水系统的范围和局限性。