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Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function [Immunology and Inflammation]
Proceedings of the National Academy of Sciences of the United States of America ( IF 11.1 ) Pub Date : 2020-03-27 Xue Zhong, Lijing Su, Yi Yang, Evan Nair-Gill, Miao Tang, Priscilla Anderton, Xiaohong Li, Jianhui Wang, Xiaoming Zhan, Diana R. Tomchick, Chad A. Brautigam, Eva Marie Y. Moresco, Jin Huk Choi, Bruce Beutler
Proceedings of the National Academy of Sciences of the United States of America ( IF 11.1 ) Pub Date : 2020-03-27 Xue Zhong, Lijing Su, Yi Yang, Evan Nair-Gill, Miao Tang, Priscilla Anderton, Xiaohong Li, Jianhui Wang, Xiaoming Zhan, Diana R. Tomchick, Chad A. Brautigam, Eva Marie Y. Moresco, Jin Huk Choi, Bruce Beutler
The small GTPase RABL3 is an oncogene of unknown physiological function. Homozygous knockout alleles of mouse Rabl3 were embryonic lethal, but a viable hypomorphic allele (xiamen [xm]) causing in-frame deletion of four amino acids from the interswitch region resulted in profound defects in lymphopoiesis. Impaired lymphoid progenitor development led to...
中文翻译：
RABL3的遗传和结构研究揭示了在淋巴样发育和功能中的重要作用[免疫学和炎症]
小GTPase RABL3是未知生理功能的癌基因。小鼠Rabl3的纯合敲除等位基因是胚胎致死的，但是一个可行的亚型等位基因（厦门[xm]）导致框内删除从开关之间的区域中的四个氨基酸导致淋巴细胞生成的严重缺陷。淋巴样祖细胞发育受损导致...
更新日期：2020-03-28
中文翻译：
RABL3的遗传和结构研究揭示了在淋巴样发育和功能中的重要作用[免疫学和炎症]
小GTPase RABL3是未知生理功能的癌基因。小鼠Rabl3的纯合敲除等位基因是胚胎致死的，但是一个可行的亚型等位基因（厦门[xm]）导致框内删除从开关之间的区域中的四个氨基酸导致淋巴细胞生成的严重缺陷。淋巴样祖细胞发育受损导致...
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