The androgen receptor (AR) is a type I nuclear hormone receptor and the primary drug target in prostate cancer due to its role as a lineage survival factor in prostate luminal epithelium. In prostate cancer, the AR cistrome is reprogrammed relative to normal prostate epithelium and particularly in cancers driven...

中文翻译：

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通过与ETS转录因子ERG直接相互作用来调节雄激素受体DNA结合活性[医学科学]

雄激素受体（AR）是I型核激素受体，是前列腺癌的主要药物靶标，因为它在前列腺腔上皮细胞中作为谱系存活因子发挥作用。在前列腺癌中，相对于正常前列腺上皮，AR Cistrome重新编程，尤其是在癌症驱动的癌症中。