Electrospinning is one of the most promising techniques for generating porous, nonwoven, and submicron fiber-based membranes for various applications such as catalysis, sensing, tissue engineering and wound healing. Wide range of biopolymers including chitosan can be used to generate submicron fibrous membranes. Owing to the extra cellular matrix (ECM) mimicking property, exudate uptake capacity, biocompatibility, antibacterial activity and biodegradability, electrospun membranes based on chitosan loaded with biologically active agents can play important role in wound healing applications. In order to improve the mechanical stability, degradation, antimicrobial property, vascularization potential and wound healing capacity, various active components such as other polymers, therapeutic agents, nanoparticles and biomolecules were introduced. Approaches such as coaxial electrospinning with other polymers have also been tried to improve the properties of chitosan membranes. To improve the mechanical stability under in vivo conditions, various crosslinking strategies ranging from physical, chemical and biological approaches were also tried by researchers. Electrospun chitosan meshes have also been designed in a highly specialized manner with specific functionalities to deal with the challenging wound environment of diabetic and burn wounds. This review provides a detailed overview of electrospun chitosan-based membranes containing various bioactive and therapeutic agents in the perspective of wound healing and skin regeneration.

中文翻译：

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含有生物活性剂和治疗剂的静电纺丝壳聚糖膜，可增强伤口愈合。

电纺丝是产生多孔，非织造和亚微米纤维基膜的最有前途的技术之一，可用于各种应用，例如催化，传感，组织工程和伤口愈合。包括壳聚糖在内的多种生物聚合物可用于产生亚微米纤维膜。由于具有细胞外基质（ECM）的模拟特性，渗出液吸收能力，生物相容性，抗菌活性和生物降解性，基于负载生物活性剂的壳聚糖的电纺膜可在伤口愈合应用中发挥重要作用。为了改善机械稳定性，降解，抗微生物性能，血管化潜力和伤口愈合能力，引入了各种活性成分，例如其他聚合物，治疗剂，纳米颗粒和生物分子。还尝试了诸如与其他聚合物共轴静电纺丝的方法来改善壳聚糖膜的性能。为了提高在体内条件下的机械稳定性，研究人员还尝试了各种交联策略，包括物理，化学和生物学方法。还已经以高度专业化的方式设计了具有特定功能的静电纺丝壳聚糖网，以应对糖尿病和烧伤创面的挑战性创面环境。这篇综述从伤口愈合和皮肤再生的角度提供了包含各种生物活性和治疗剂的基于静电纺丝的壳聚糖膜的详细概述。为了提高在体内条件下的机械稳定性，研究人员还尝试了多种交联策略，包括物理，化学和生物学方法。还已经以高度专业化的方式设计了具有特定功能的静电纺丝壳聚糖网，以应对糖尿病和烧伤创面的挑战性创面环境。这篇综述从伤口愈合和皮肤再生的角度提供了包含各种生物活性和治疗剂的基于静电纺丝的壳聚糖膜的详细概述。为了提高在体内条件下的机械稳定性，研究人员还尝试了多种交联策略，包括物理，化学和生物学方法。还已经以高度专业化的方式设计了具有特定功能的静电纺丝壳聚糖网，以应对糖尿病和烧伤创面的挑战性创面环境。这篇综述从伤口愈合和皮肤再生的角度提供了包含各种生物活性和治疗剂的基于静电纺丝的壳聚糖膜的详细概述。还已经以高度专业化的方式设计了具有特定功能的静电纺丝壳聚糖网，以应对糖尿病和烧伤创面的挑战性创面环境。这篇综述从伤口愈合和皮肤再生的角度提供了包含各种生物活性和治疗剂的基于静电纺丝的壳聚糖膜的详细概述。还已经以高度专业化的方式设计了具有特定功能的静电纺丝壳聚糖网，以应对具有挑战性的糖尿病和烧伤创面的创面环境。这篇综述从伤口愈合和皮肤再生的角度提供了包含各种生物活性和治疗剂的基于静电纺丝的壳聚糖膜的详细概述。