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Effects of fullerene C60 supplementation on gut microbiota and glucose and lipid homeostasis in rats.
Food and Chemical Toxicology ( IF 3.9 ) Pub Date : 2020-03-28 , DOI: 10.1016/j.fct.2020.111302 Siniša Đurašević 1 , Gorana Nikolić 2 , Ana Todorović 3 , Dunja Drakulić 3 , Snežana Pejić 3 , Vesna Martinović 4 , Dragana Mitić-Ćulafić 1 , Dragana Milić 5 , Tatjana J Kop 6 , Nebojša Jasnić 1 , Jelena Đorđević 1 , Zoran Todorović 7
Food and Chemical Toxicology ( IF 3.9 ) Pub Date : 2020-03-28 , DOI: 10.1016/j.fct.2020.111302 Siniša Đurašević 1 , Gorana Nikolić 2 , Ana Todorović 3 , Dunja Drakulić 3 , Snežana Pejić 3 , Vesna Martinović 4 , Dragana Mitić-Ćulafić 1 , Dragana Milić 5 , Tatjana J Kop 6 , Nebojša Jasnić 1 , Jelena Đorđević 1 , Zoran Todorović 7
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The effects of twelve weeks of supplementation with fullerene C60 olive/coconut oil solution on a broad spectrum of parameters in rats were examined. The tissue bioaccumulation of C60 was shown to be tissue-specific, with the liver, heart, and adrenal glands being the organs of the greatest, and the kidney, brain, and spleen being the organs of the smallest accumulation. C60 did not change aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase serum activities level, nor the damage of liver cells DNA. There were no effects of fullerene on prooxidant-antioxidant balance in the liver, kidney, spleen, heart, and brain, nor any visible harmful effects on the liver, heart, aorta, spleen, kidney, and small intestine histology. Fullerene changed the gut microbiota structure towards the bacteria that ameliorate lipid homeostasis, causing a serum triglycerides concentration decrease. However, C60 significantly increased the insulin resistance, serum ascorbate oxidation, and brain malondialdehyde and advanced oxidation protein products level. The deteriorative effects of C60 on the brain and serum could be attributed to the specific physicochemical composition of these tissues, potentiating the C60 aggregation or biotransformation as the key element of its pro-oxidative action.
中文翻译：
补充富勒烯C60对大鼠肠道菌群以及葡萄糖和脂质稳态的影响。
检查了富勒烯C60橄榄/椰子油溶液补充十二周后对大鼠各种参数的影响。C60的组织生物蓄积具有组织特异性，其中肝脏，心脏和肾上腺是最大的器官，肾脏，脑和脾脏是最小的器官。C60没有改变天冬氨酸转氨酶，丙氨酸转氨酶和碱性磷酸酶的血清活性水平，也没有改变肝细胞DNA的损伤。富勒烯对肝脏，肾脏，脾脏，心脏和大脑中的抗氧化剂-抗氧化剂平衡没有影响，对肝脏，心脏，主动脉，脾脏，肾脏和小肠的组织学也没有任何可见的有害影响。富勒烯改变了肠道菌群结构，使其趋向于改善脂质稳态的细菌，导致血清甘油三酸酯浓度降低。但是，C60显着提高了胰岛素抵抗，血清抗坏血酸的氧化以及脑丙二醛和高级氧化蛋白产物的水平。C60对大脑和血清的恶化作用可能归因于这些组织的特定理化成分，从而使C60聚集或生物转化成为其促氧化作用的关键要素。
更新日期：2020-03-28
中文翻译：
补充富勒烯C60对大鼠肠道菌群以及葡萄糖和脂质稳态的影响。
检查了富勒烯C60橄榄/椰子油溶液补充十二周后对大鼠各种参数的影响。C60的组织生物蓄积具有组织特异性，其中肝脏，心脏和肾上腺是最大的器官，肾脏，脑和脾脏是最小的器官。C60没有改变天冬氨酸转氨酶，丙氨酸转氨酶和碱性磷酸酶的血清活性水平，也没有改变肝细胞DNA的损伤。富勒烯对肝脏，肾脏，脾脏，心脏和大脑中的抗氧化剂-抗氧化剂平衡没有影响，对肝脏，心脏，主动脉，脾脏，肾脏和小肠的组织学也没有任何可见的有害影响。富勒烯改变了肠道菌群结构，使其趋向于改善脂质稳态的细菌，导致血清甘油三酸酯浓度降低。但是，C60显着提高了胰岛素抵抗，血清抗坏血酸的氧化以及脑丙二醛和高级氧化蛋白产物的水平。C60对大脑和血清的恶化作用可能归因于这些组织的特定理化成分，从而使C60聚集或生物转化成为其促氧化作用的关键要素。
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