Maintaining proper blood flow is critical in promoting good health. This study examined whether oral consumption of a bred variety of oriental melon for high serine protease (OMS) dampened collagen/epinephrine (CE)-induced vascular thrombosis in rats in comparison with a regular cultivar (OM). Freeze-dried OM or OMS were administered by oral gavage for 4 weeks. In a CE-induced thrombotic condition, OMS significantly reduced thrombogenesis by inhibiting both cyclooxygenase-1-mediated thromboxane B₂ production and intrinsic blood coagulation pathways. It also stimulated fibrin clot lysis by activating tissue-type plasminogen activator. Besides, OMS restored CE-mediated alterations in adhesion molecules and endothelial nitric oxide synthase, thereby resulting in vasodilation. OM showed similar tendencies, but not statistically equivalent. The current findings, for the first time, suggest that plant SP from OMS may have the potential to protect endothelial and vascular dysfunctions that can be encountered by unintentional exposure to thrombotic risk factors in daily life.

维持适当的血液流通对促进健康至关重要。这项研究检查了与普通品种（OM）相比，口服食用高浓度的丝氨酸​​蛋白酶（OMS）东方瓜品种是否能减轻大鼠胶原/肾上腺素（CE）引起的血管血栓形成。通过口腔管饲法将冷冻干燥的OM或OMS施用4周。在CE诱发的血栓形成情况下，OMS通过抑制环氧合酶1介导的血栓烷B ₂显着减少血栓形成产生和固有的凝血途径。它还通过激活组织型纤溶酶原激活剂来刺激纤维蛋白凝块溶解。此外，OMS恢复了CE介导的粘附分子和内皮一氧化氮合酶的改变，从而导致血管舒张。OM显示出相似的趋势，但在统计学上并不等效。目前的发现首次表明，来自OMS的植物SP可能具有保护内皮和血管功能障碍的潜力，而日常生活中无意中暴露于血栓性危险因素可能会遇到这种问题。