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An integrated approach to the investigation of antioxidant properties by potentiometry
Analytica Chimica Acta ( IF 5.7 ) Pub Date : 2020-05-01 , DOI: 10.1016/j.aca.2020.03.041
A V Ivanova 1 , E L Gerasimova 1 , E R Gazizullina 1
Affiliation  

An analytical methodology is proposed for a comprehensive study of antioxidant properties of various objects based on the implementation of various mechanisms of antioxidant action. In order to interpret results regarding the action of antioxidants in living organisms it is proposed to adhere to certain requirements for research methods of antioxidant properties, for oxidizing agents of a radical and non-radical nature. The developed integrated approach consists in using the potentiometry method and is based on the antioxidant capacity determination which is founded on the interaction of antioxidants with the К3[Fe(CN)6] by the ET-mechanism and the conjugation mechanism and the antiradical capacity determination based on the interaction of antioxidants with peroxyl radicals by the HAT-mechanism. Individual antioxidants of natural origin, plant materials extracts as well as synthesized 6-nitro-1,2,4-triazoloazin containing polyphenols fragments, which are complex conjugated structures, have been investigated. It has been shown that in the antioxidants study it is advisable to use the integrated approach that will allow to evaluate antioxidant properties from the point of view of various antioxidants action mechanisms.

中文翻译:

通过电位测定法研究抗氧化特性的综合方法

基于各种抗氧化作用机制的实施,提出了一种分析方法,用于综合研究各种物体的抗氧化特性。为了解释关于抗氧化剂在生物体中作用的结果,建议遵守抗氧化特性研究方法的某些要求,对于自由基和非自由基性质的氧化剂。开发的综合方法包括使用电位法,并基于抗氧化能力测定,该测定建立在抗氧化剂与 К3[Fe(CN)6] 相互作用的基础上,通过 ET 机制和共轭机制以及抗自由基能力测定基于通过 HAT 机制的抗氧化剂与过氧自由基的相互作用。天然来源的个别抗氧化剂,植物材料提取物以及合成的 6-nitro-1,2,4-triazoloazin 含有多酚片段,它们是复杂的共轭结构,已经进行了研究。已经表明,在抗氧化剂研究中,建议使用综合方法,从各种抗氧化剂作用机制的角度评估抗氧化特性。
更新日期:2020-05-01
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