BACKGROUND Patients with chronic obstructive pulmonary disease (COPD) in advanced disease stage who need long-term home oxygen therapy (LTHOT) have difficulty participating in outpatient pulmonary rehabilitation (PR) programs due to the severity of their disease, limitations involving transportation and mobility, high costs and issues related to patients' safety and individual needs. Unsupervised home-based physical training (PT) is frequently used. The main objective of this study was to investigate the effectiveness of a supervised home-based PT program on exercise capacity and other outcomes in patients with COPD on LTHOT METHODS: In a randomized clinical trial, patients with COPD on LTHOT were allocated into two groups: supervised physical training group (PTG), consisting of patients who received home-based supervised muscle strength and endurance training in twice-weekly 60-minute sessions for 12 weeks; and unsupervised activity booklet group (BG), consisting of patients who received a booklet advising them to perform exercise twice a week during 12 weeks. All participants were assessed before and after the intervention in terms of exercise capacity (6-Minute Step-Test (6MST) and the 1-Minute Sit-to-Stand Test [STST]); dyspnea (Medical Research Council scale [MRC]); fatigue (Fatigue Severity Scale [FSS-BR]); and health status (COPD Assessment Test [CAT]) RESULTS: 44 patients were assessed (70±8 years, FEV1: 33±14%predicted) (PTG, n=22; BG, n=22). Only PTG presented significant improvement in 6MST (21±9 vs 14±1, p=0.001), MRC (3.3±1.0 vs 3.9±0.9, p=0.013), FSS-BR (5.0±1.4 vs 5.2±1.3, p=0.015) and CAT (21±8 vs 26±6, p=0.001). No adverse effects were observed. CONCLUSIONS Supervised home-based PT was effective and safe in improving exercise capacity, dyspnea, fatigue and health status in patients with COPD on LTHOT.

中文翻译：

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慢性阻塞性肺病患者长期家庭氧疗的受监督家庭体育训练的有效性和安全性：随机试验

背景 需要长期家庭氧疗 (LTHOT) 的晚期慢性阻塞性肺疾病 (COPD) 患者由于疾病的严重性、涉及交通和行动能力的限制，难以参与门诊肺康复 (PR) 计划，高成本和与患者安全和个人需求相关的问题。经常使用无监督的家庭体育训练 (PT)。本研究的主要目的是调查受监督的家庭 PT 计划对 LTHOT 方法的 COPD 患者运动能力和其他结果的有效性：在一项随机临床试验中，LTHOT 的 COPD 患者被分为两组：监督体能训练组（PTG），由接受家庭监督肌肉力量和耐力训练的患者组成，每周两次，每次 60 分钟，持续 12 周；和无人监督的活动手册组 (BG)，由收到手册的患者组成，建议他们在 12 周内每周进行两次锻炼。所有参与者在干预前后都接受了运动能力评估（6 分钟踏步测试 (6MST) 和 1 分钟坐立测试 [STST]）；呼吸困难（医学研究委员会量表 [MRC]）；疲劳（疲劳严重程度量表 [FSS-BR]）；和健康状况（COPD 评估测试 [CAT]） 结果：评估了 44 名患者（70±8 岁，FEV1：预测的 33±14%）（PTG，n=22；BG，n=22）。只有 PTG 在 6MST (21±9 vs 14±1, p=0.001), MRC (3.3±1.0 vs 3.9±0.9, p=0.013), FSS-BR (5.0±1.4 vs 5.2±1.3, p= 0. 015）和 CAT（21±8 对 26±6，p=0.001）。没有观察到不良反应。结论 有监督的家庭 PT 在改善 LTHOT 的 COPD 患者的运动能力、呼吸困难、疲劳和健康状况方面是有效且安全的。