The fermented products of various materials with the mushroom Cordyceps militaris mycelia and silkworm pupa changed the bioactive compounds and increased the biological activity. Fermentation of strawberry (Fragaria x ananassa Duch. cv Sulhyang) mixed with silkworm pupa (Bombyx mori) using the mushroom Cordyceps militaris mycelia was undertaken using a solid culture. Previously frozen strawberries were fermented with 0, 25 and 50% of silkworm pupa (FS, FSP25, FSP50, respectively) or silkworm pupa (FP) using Cordyceps militaris, then the fermented products and non-fermented strawberry (NS) were extracted with 50 or 70% EtOH, or distilled water to determine the optimal fermentation conditions with regards to its anti-adipogenesis effect. The high-performance liquid chromatograph (HPLC) analysis showed that the levels of 7 bioactive compounds were changed after fermentation. Additionally, extracts of FSP25, FSP50 and FP showed different amounts of inhibition of adipogenesis in the 3T3-L1 cell line. FSP25 and FSP50 were most effective. FSP25E50, the 50% EtOH extract of FSP25, inhibited expression of the PPAR-γ pathway signaling. These results indicated that fermented strawberry might be used as a nutraceutical and functional food to give anti-adipogenesis activity.

带有菌丝虫草菌丝体和蚕various的各种材料的发酵产物改变了生物活性化合物并提高了生物活性。使用固态培养物，用蘑菇mil虫草菌丝体发酵混合了蚕（Bombyx mori）的草莓（Fragaria x ananassa Duch。cv Sulhyang）。使用虫草，将先前冷冻的草莓分别用0％，25％和50％的蚕（FS，FSP25，FSP50）或蚕（FP）发酵。，然后用50％或70％的乙醇或蒸馏水提取发酵产物和非发酵草莓（NS），以确定就其抗脂肪形成作用而言的最佳发酵条件。高效液相色谱（HPLC）分析表明，发酵后7种生物活性化合物的含量发生了变化。另外，FSP25，FSP50和FP的提取物在3T3-L1细胞系中显示出不同程度的脂肪生成抑制作用。FSP25和FSP50最有效。FSP25E50是FSP25的50％EtOH提取物，可抑制PPAR-γ途径信号的表达。这些结果表明，发酵草莓可以用作具有抗脂肪形成活性的营养食品和功能食品。