5-Fluorouracil (5-FU) is widely used as a chemotherapeutic drug for the treatment of cancer but it has toxic side effects. It can induce severe intestinal damage and even lead to death. The purpose of this study was to investigate whether milk fermented with Lactobacillus rhamnosus FLRH93 could alleviate intestinal damage induced by 5-FU. The results of injury intervention in a mouse model showed that milk fermented with Lb. rhamnosus FLRH93 significantly ameliorated intestinal injury caused by 5-FU. The results of hematoxylin and eosin staining showed that mice fed Lb. rhamnosus FLRH93 preserved the villus/crypt ratio and reduced the loss of goblet cells in ileum sections of 5-FU-treated animal. Further, administration of fermented milk upregulated expression of Bcl-2 in the intestinal tract and downregulated the expression of NLRP3, thus reducing the production of inflammatory factors interleukin 1-β and tumor necrosis factor-α. The survival rate of mice treated with fermented milk was twice that of mice not fed fermented milk after continuous oral administration of 5-FU. In conclusion, Lb. rhamnosus FLRH93 has positive effects on body injury and could be used to prevent intestinal damage caused by cancer chemotherapy.

中文翻译：

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鼠李糖乳杆菌FLRH93可防止5-氟尿嘧啶诱导的小鼠肠道损伤。

5-氟尿嘧啶（5-FU）被广泛用作治疗癌症的化学治疗药物，但有毒副作用。它会引起严重的肠道损伤，甚至导致死亡。这项研究的目的是调查用鼠李糖乳杆菌FLRH93发酵的牛奶是否可以减轻5-FU引起的肠道损伤。小鼠模型中的损伤干预结果表明，牛奶被Lb发酵。鼠李糖FLRH93显着改善了5-FU引起的肠道损伤。苏木精和曙红染色的结果表明，小鼠喂养了Lb。鼠李糖菌FLRH93保留了绒毛/隐窝比率，并减少了5-FU处理动物回肠切片中杯状细胞的损失。此外，服用发酵乳可上调肠道Bcl-2的表达，并下调NLRP3的表达，因此减少了炎性因子白介素1-β和肿瘤坏死因子-α的产生。连续口服5-FU后，用发酵乳处理的小鼠的存活率是未喂养发酵乳的小鼠的两倍。总之，磅。鼠李糖FLRH93对身体伤害有积极作用，可用于预防癌症化学疗法对肠道造成的损害。