MnO Nanoparticles Embedded in Functional Polymers as T1 Contrast Agents for Magnetic Resonance Imaging,ACS Applied Nano Materials

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MnO Nanoparticles Embedded in Functional Polymers as T1 Contrast Agents for Magnetic Resonance Imaging
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2020-03-27 , DOI: 10.1021/acsanm.0c00474
Michele Mauri ₁ , Veronica Collico ₂ , Lucia Morelli ₂ , Pradip Das ₂ , Isabel García _{3,

4} , Jesus Penaranda Avila ₂ , Michela Bellini ₂ , Rany Rotem ₂ , Marta Truffi ₅ , Fabio Corsi _{5,

6} , Roberto Simonutti ₁ , Luis M. Liz-Marzán _{3,

4,

7} , Miriam Colombo ₂ , Davide Prosperi _{2,

6}

Affiliation

The design and development of contrast agents (CAs) for magnetic resonance imaging (MRI) in clinical analysis is expected to improve the image spatial resolution and to increase the detection sensitivity, especially regarding neurological disorders and cancer disease. In particular, advanced CAs for T₁-weighted images are investigated to achieve the sensitive detection of early-stage primary tumors or brain metastases. In this study, we present a strategy toward diagnostic T₁ CAs for MRI, based on polymer-modified MnO nanoparticles (NPs). Two different nanosystems were synthesized, consisting of (1) colloidal MnO nanocrystals wrapped by a multidentate amphiphilic polymer and (2) MnO nanocrystals embedded within poly(lactic-co-glycolic acid) (PLGA) NPs. These nanosystems were compared in terms of their MRI contrast power and biological safety. The latter system combines the excellent biocompatibility of PLGA with the unique magnetic properties of MnO NPs and allows sustained contrast enhancement over time. Longitudinal relaxivities of both MnO composite nanomaterials proved to be higher than those of commercial Gd-based CAs and Teslascan, both in phosphate-buffered saline and in plasma, also exhibiting low cytotoxicity. The high relaxation rates achieved with these contrast enhancers are promising toward future application in in vivo imaging.

中文翻译：

MnO纳米粒子作为T ₁造影剂嵌入功能聚合物中，用于磁共振成像。

有望在临床分析中设计和开发用于磁共振成像（MRI）的造影剂（CA），以改善图像空间分辨率并提高检测灵敏度，尤其是在神经系统疾病和癌症疾病方面。特别是，研究了针对T ₁加权图像的先进CA，以实现对早期原发肿瘤或脑转移的敏感检测。在这项研究中，我们提出了一种基于聚合物修饰的MnO纳米颗粒（NPs）的诊断T ₁ CA MRI的策略。两种不同的纳米系统合成，由通过嵌入聚内的多齿两亲性聚合物和（2）的MnO纳米晶体包裹（1）的MnO胶体纳米晶体（乳酸-共-乙醇酸（PLGA）NP。比较了这些纳米系统的MRI对比功能和生物安全性。后一种系统将PLGA的出色生物相容性与MnO NPs的独特磁性相结合，并可以随时间持续增强对比度。在磷酸盐缓冲液和血浆中，两种MnO复合纳米材料的纵向弛豫率均高于商用Gd基CA和Teslascan，其细胞毒性也较低。用这些对比度增强剂获得的高松弛率有望用于将来在体内成像中的应用。

更新日期：2020-03-27

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