N-Methylation and Trideuteromethylation of Amines via Magnesium-Catalyzed Reduction of Cyclic and Linear Carbamates.,Organic Letters

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N-Methylation and Trideuteromethylation of Amines via Magnesium-Catalyzed Reduction of Cyclic and Linear Carbamates.
Organic Letters ( IF 4.9 ) Pub Date : 2020-03-27 , DOI: 10.1021/acs.orglett.0c00988
Marc Magre ₁ , Marcin Szewczyk ₁ , Magnus Rueping _{1,

2}

Affiliation

A new reduction of carbamates to N-methyl amines is presented. The magnesium-catalyzed reduction reaction allows the conversion of cyclic and linear carbamates, including N-Boc protected amines, into the corresponding N-methyl amines and amino alcohols which are of significant interest due to their presence in many biologically active molecules. Furthermore, the reduction can be extended to the formation of N-trideuteromethyl labeled amines.

中文翻译：

胺的镁的N-甲基化和三氘甲基化，通过镁催化的环状和线性氨基甲酸酯的还原。

提出了将氨基甲酸酯新还原为N-甲基胺的方法。镁催化的还原反应使包括N- Boc保护的胺在内的环状和线性氨基甲酸酯转化为相应的N-甲基胺和氨基醇，由于它们在许多生物活性分子中的存在，它们引起了人们的极大兴趣。此外，该还原可以扩展到N-三苯甲基亚甲基标记的胺的形成。

更新日期：2020-04-24

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