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Nickel-Catalyzed Cross-Coupling of Alkyl Carboxylic Acid Derivatives with Pyridinium Salts via C-N Bond Cleavage.
Organic Letters ( IF 4.9 ) Pub Date : 2020-03-27 , DOI: 10.1021/acs.orglett.0c00554
Feba Thomas Pulikottil 1 , Ramadevi Pilli 1 , Rohith Valavil Suku 1 , Ramesh Rasappan 1
Affiliation  

The electrophile–electrophile cross-coupling of carboxylic acid derivatives and alkylpyridinium salts via C–N bond cleavage is developed. The method is distinguished by its simplicity and steers us through a variety of functionalized ketones in good to excellent yields. Besides acid chlorides, carboxylic acids were also employed as acylating agents, which enabled us to incorporate acid-sensitive functional groups such as MOM, BOC, and acetal. Control experiments with TEMPO revealed a radical pathway.

中文翻译:

通过CN键裂解,镍催化烷基羧酸衍生物与吡啶鎓盐的交叉偶联。

羧酸衍生物和烷基吡啶鎓盐通过C–N键断裂的亲电-亲电交叉偶联得到了发展。该方法以其简单性而著称,可指导我们选择各种功能化的酮,产率高至优异。除酰氯外,羧酸还用作酰化剂,这使我们能够结合酸敏感性官能团,例如MOM,BOC和乙缩醛。使用TEMPO进行的对照实验揭示了一个基本途径。
更新日期:2020-04-24
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