Nickel-Catalyzed Cross-Coupling of Alkyl Carboxylic Acid Derivatives with Pyridinium Salts via C-N Bond Cleavage.,Organic Letters

当前位置： X-MOL 学术 › Org. Lett. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Nickel-Catalyzed Cross-Coupling of Alkyl Carboxylic Acid Derivatives with Pyridinium Salts via C-N Bond Cleavage.
Organic Letters ( IF 4.9 ) Pub Date : 2020-03-27 , DOI: 10.1021/acs.orglett.0c00554
Feba Thomas Pulikottil ₁ , Ramadevi Pilli ₁ , Rohith Valavil Suku ₁ , Ramesh Rasappan ₁

Affiliation

The electrophile–electrophile cross-coupling of carboxylic acid derivatives and alkylpyridinium salts via C–N bond cleavage is developed. The method is distinguished by its simplicity and steers us through a variety of functionalized ketones in good to excellent yields. Besides acid chlorides, carboxylic acids were also employed as acylating agents, which enabled us to incorporate acid-sensitive functional groups such as MOM, BOC, and acetal. Control experiments with TEMPO revealed a radical pathway.

中文翻译：

通过CN键裂解，镍催化烷基羧酸衍生物与吡啶鎓盐的交叉偶联。

羧酸衍生物和烷基吡啶鎓盐通过C–N键断裂的亲电-亲电交叉偶联得到了发展。该方法以其简单性而著称，可指导我们选择各种功能化的酮，产率高至优异。除酰氯外，羧酸还用作酰化剂，这使我们能够结合酸敏感性官能团，例如MOM，BOC和乙缩醛。使用TEMPO进行的对照实验揭示了一个基本途径。

更新日期：2020-04-24

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11