Development of a C2-Symmetric Chiral aza Spirocyclic Diol.,Organic Letters

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Development of a C2-Symmetric Chiral aza Spirocyclic Diol.
Organic Letters ( IF 4.9 ) Pub Date : 2020-03-27 , DOI: 10.1021/acs.orglett.0c00858
Weicong Guo ₁ , Qinzhe Liu ₁ , Jijun Jiang ₁ , Jun Wang ₁

Affiliation

A C₂-symmetric chiral spirocyclic diol aza-SPINOL containing a spirooxindole scaffold has been designed, synthesized, and optically resolved. The product could be synthesized on gram scale in an overall yield of 22%. Moreover, elaborations of aza-SPINOL to other chiral ligands as well as the preliminary investigation of the related bisphosphine ligand in the desymmetrization of bisallylic amide were reported.

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