Respiratory syncytial virus is the leading cause of lower respiratory tract infection among infants. RSV is a priority for vaccine development. In this study, we investigate the potential effectiveness of a two-vaccine strategy aimed at mothers-to-be, thereby boosting maternally acquired antibodies of infants, and their household cohabitants, further cocooning infants against infection. We use a dynamic RSV transmission model which captures transmission both within households and communities, adapted to the changing demographics and RSV seasonality of a low-income country. Model parameters were inferred from past RSV hospitalisations, and forecasts made over a 10-year horizon. We find that a 50% reduction in RSV hospitalisations is possible if the maternal vaccine effectiveness can achieve 75 days of additional protection for newborns combined with a 75% coverage of their birth household co-inhabitants (∼7.5% population coverage).

中文翻译：

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通过为准妈妈及其家属接种疫苗减少低收入国家的RSV住院

呼吸道合胞病毒是婴儿下呼吸道感染的主要原因。RSV是疫苗开发的重点。在这项研究中，我们调查了针对准妈妈的两疫苗策略的潜在有效性，从而增强了婴儿及其家庭同伴的母体获得性抗体，进一步使婴儿免受感染。我们使用动态RSV传播模型来捕获家庭和社区内的传播，以适应低收入国家不断变化的人口统计和RSV季节性。模型参数是根据过去的RSV住院情况得出的，并在10年内进行了预测。